Road map to a longer life

06.10.2017, 10:11 | Wissenschaft | Autor: | Jetzt kommentieren


Tissues respond very differently to an ageing ameliorating intervention

In old age a variety of cellular processes decline and the risk to develop age-related diseases such as Alzheimer’s, Parkinson’s or Diabetes increases dramatically. But does ageing affect all organs and tissues in the body in the same way? And should drugs that are developed to improve health in old age have the same effect on every organ? Now scientists from the Max Planck Institute for Biology of Ageing in Cologne have shown in flies that tissues respond very differently to reduced insulin signalling, which is known to extend lifespan in many organisms, from flies to mice, and possibly people. Importantly, those different responses can lead to extensions in lifespan themselves.

Scientists have known for many years that lowered activity of the insulin signalling network can extend lifespan and improve health during ageing, but it is still not understood how. The insulin signalling network responds to nutrient availability and stress levels and regulates development, growth, reproduction and lifespan. To understand how different tissues and organs respond, researchers in the team of Linda Partridge, director at the Max Planck Institute for Biology of Ageing and the UCL Institute of Healthy Ageing in London, analysed which proteins are produced in the brain, muscle, gut and fat body of fruit flies when insulin signalling is reduced. With this they generated a proteomic map of insulin signalling.

Each tissue responds differently

“We mapped out which proteins changed in which tissues when insulin signalling is reduced and could see that each tissue in the fly responds differently. There were only two proteins out of 6000 we analysed, which were regulated in all tissues - all others were to some degree tissue-specific”, explains Luke Tain, lead author of the study. “For example, if we reduce systemic insulin signalling, the gut responds by producing proteins for ensuring protein quality control.” This response of the gut can lead to an extension in lifespan itself: even without lowered activity of the insulin network, an increasing protein quality control only in the gut was sufficient to prolong lifespan in flies. However, the same treatment in the fat of the fly had no effect on its lifespan.

Tissue-targeted pharmacological agents

These results show how complex the response of different organs to interventions that improve health during ageing can be. “Our study opens up new possibilities for development of preventive medicine for diseases associated with ageing. In the future we could target a specific tissue with a drug, to the benefit of the whole organism. This would reduce the risk of unwanted side effects and alleviate a lot of the suffering in patients and the aged”, says Tain.

Weitere Informationen:
- https://www.age.mpg.de/public-relations/press-material/press-releases/detail/news/detail/News/road-map-to-a-longer-life/
- http://msb.embopress.org/content/13/9/939.long

Quelle: idw


Weitere Nachrichten zum Thema
  • BildThe end of the road for pathogens (14.01.2014, 14:10)
    Scientists prove benefit of textiles with antiviral and antibacterial effectBÖNNIGHEIM (dh/msz/ri) As part of an AiF research project (AiF no. N 17407), scientists from the Hohenstein Institute in Bönnigheim (Germany) have, for the first time,...
  • BildHours of Service Regulations and Road Safety (27.08.2013, 16:10)
    Road accidents involving heavy commercial vehicles often lead to severe damages and loss of lives. Truck driver fatigue plays a contributing role in many of these accidents. In their efforts to increase road safety, governments world-wide are...
  • BildExecutive MBA "On The Road" (Süd- und Nordtour) (28.09.2012, 12:10)
    Das EMBA-Team der RWTH Aachen International Academy ist „On the Road“. Für alle diejenigen, die nicht an einer der Informationsveranstaltungen in Aachen teilnehmen konnten, ist das EMBA-Team ab dem 23.10. in ganz Deutschland unterwegs. Viktoria...
  • BildSound level around seriously ill patients "like a busy road" (17.09.2012, 16:10)
    Seriously ill patients in intensive care units are being cared for in environments with sound levels more than 20 dB higher than the WHO’s recommendations. This is shown by a study carried out in partnership between the University of Gothenburg,...
  • BildOn the road to Sustainable Uses of Baltic Marine Resources (10.09.2010, 11:00)
    The project “Submariner - Sustainable Uses of Baltic Marine Resources” will turn the Baltic Sea into a model region by fostering both sustainable economic development and improved environmental conditions through new maritime products and...
  • BildEnergieeffiziente und Klima schonende Antriebskonzepte für Off-Road-Nutzfahrzeuge (24.06.2010, 12:00)
    Im Forschungsprojekt "LiB-OFF-Road" entwickelt die Fachhochschule Köln gemeinsam mit verschiedenen Projektpartnern energieeffiziente und Klima schonende Antriebskonzepte für Off-Road-Nutzfahrzeuge.Auch Off-Road-Nutzfahrzeuge der Land- und...
  • BildOn the road to quantum world with spoke wheels (28.09.2008, 21:00)
    How heavy or how big can an object be before losing its quantum properties and obeying to the laws of classical physics? This question drives many research groups all around the globe. Answers still remain to be given as currently there are no...
  • BildParallel-kinematic LBF® road-street simulator reproduces load standards realistically and shortens t (08.05.2008, 17:00)
    The Fraunhofer LBF, headed by Prof. Dr.-Ing. Holger Hanselka, presents the fully kinematic road-street simulator, its enhanced and worldwide-patented biaxial wheel test technology at the Automotive Testing Expo in Stuttgart. The newly developed...
  • BildThe Road -- *A Meeting Place (30.11.2006, 18:00)
    We have all traveled on roads. A road may be a way to get from A to B or it may be an adventure. The interaction along our roads has now been mapped, and one of the conclusions is that the road is used in a way that makes it similar to a local...
  • BildRoad Tour - RoboCup Junior Weltmeisterschaft 2006 (08.12.2005, 12:00)
    Am Montag, 12. Dezember 2005, 17.15 Uhr, ist die Road Tour RoboCup Junior Weltmeisterschaft 2006 am Mathematischen Institut der Universität Göttingen bei Prof. Dieter Hogrefe (Institut für Informatik), Hörsaal Maximum, Bunsenstrasse 3-5 in...

Ähnliche Themen in den JuraForen


Kommentar schreiben

9 - Dr ei =

Bisherige Kommentare zur Nachricht (0)

(Keine Kommentare vorhanden)



Fragen Sie einen Anwalt!
Anwälte sind gerade online.
Schnelle Antwort auf Ihre Rechtsfrage.

JuraForum-Newsletter

Kostenlose aktuelle Urteile und Rechtstipps per E-Mail:

Top 10 Orte in der Anwaltssuche

JuraForum-Suche

Durchsuchen Sie hier JuraForum.de nach bestimmten Begriffen:

© 2003-2017 JuraForum.de — Alle Rechte vorbehalten. Keine Vervielfältigung, Verbreitung oder Nutzung für kommerzielle Zwecke.